Study: Weight-Loss Surgery Cuts Cancer Risk in Women



By Denise Mann

WEDNESDAY, June 24, 2009 ( — Weight-loss surgery can sometimes reverse type 2 diabetes and ease other obesity-related conditions. Now, new research suggests that obese women who undergo bariatric surgery experience a 42% drop in their cancer risk.

Exactly why this occurs and whether it’s also true for obese men is not yet clear. Obesity is a known risk factor for colon, breast, endometrial, kidney, and esophageal cancers. However, the researchers found that the surgery-related weight loss and drop in caloric intake did not seem to be solely responsible for the decline in the women’s cancer risk, according to the report in the July issue of Lancet Oncology.

“Evidently, one or several risk factors for cancer are favorably influenced by bariatric surgery in women,” says lead study author Lars Sjöström, MD, PhD, a professor of medicine at Sahlgrenska University Hospital, in Gothenburg, Sweden.

In the study, researchers followed two groups for an average of 10.9 years—2,010 men and women who had weight-loss surgery, and 2,037 obese people who did not undergo surgery. Those who had the surgery lost roughly 44 pounds, compared to just 3 pounds in those who did not. During the 10-year period, 117 people who had surgery developed cancer, as did 169 of their counterparts who tried to lose weight nonsurgically.

There were 79 cancers diagnosed in women who had surgery, compared with 130 cancers in the other women; a wide variety of cancer types were lower in women who had bariatric surgery. Still, the researchers did not find a statistical link specifically between weight loss or caloric intake after surgery and the reduction in cancer risk. They also found no cancer risk reduction for men who had surgery.

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Why there might also be a link in men

However, there were more women than men in the study. A larger study might detect an effect in men, too, the researchers note. Still, this is not the first study to suggest that weight-loss surgery does not reduce cancer risk in men, and it’s possible that hormonal differences between the sexes may play a role.

For example, higher levels of the female sex hormone estrogen can stimulate the growth of breast and endometrial cancers, and fat cells are known to produce estrogen. “Women are more sensitive to estrogen, so you might expect to see a major difference in estrogen-related cancers after surgical weight loss,” says Neil Hutcher, MD, the director of bariatric surgery at St. Mary's Bon Secours Hospital, in Richmond, Va.

It’s also possible that obesity-related cancers that are more common in men—such as colon, rectal, and kidney cancers—may simply take longer to manifest than weight-related cancers in women, according to an editorial by Andrew G. Renehan, MD, of the University of Manchester, in the U.K. Therefore, a longer study may show an advantage for men.

“I think the message here is that obesity increases the risk of cancer, [so] more aggressive screening for those cancers in obese people is indicated, especially breast, uterine, and colon cancers,” says Gregg H. Jossart, MD, of Laparoscopic Associates of San Francisco, who was not involved in the study. “Finally, sustained weight loss through obesity surgery probably does decrease the risk of death from colon cancer—men are most at risk for this—but the study population is simply not large enough to determine this."

The weight-loss surgery techniques used in the study may also partly explain the findings. The majority of participants had vertical banded gastroplasty (commonly known as stomach stapling), in which the upper stomach is stapled to create a smaller pouch; some had adjustable gastric banding, in which a silicone band is placed around the top of the upper part of the stomach to restrict food intake.

Fewer than 300 people in the study had gastric bypass surgery, a more dramatic technique in which the surgeon creates a golf-ball-shaped pouch to curb food intake. Although a reduction in cancer risk was seen with all three techniques, some experts believe that gastric bypass surgery may one day be shown to be more effective than the other two.

Next page: How is gastric bypass different from other techniques?

In gastric bypass surgery, a portion of the stomach is stapled to create the pouch and the intestines are rerouted to the new, smaller stomach. Surgeons rearrange the anatomy—and that may change the hormonal milieu and affect cancer risk, Dr. Hutcher explains.

Rearranging the anatomy is thought to have an unknown effect on the body; some people with type 2 diabetes who undergo this type of surgery experience a drop in insulin resistance and other diabetes-related problems before they even lose weight. (However, this is not true for everyone; many people who undergo weight-loss surgery still have type 2 diabetes even after they lose weight.)

”There is no question that obesity increases the risk for certain cancers, and that losing weight can help reduce these risks,” says Shawn Garber, MD, the chief of bariatric surgery at Mercy Medical Center, in Rockville Center, N.Y., and the head of the New York Bariatric Group, in New Hyde Park, N.Y. “Stomach stapling has fallen out of favor because it is not as effective as other bariatric procedures.”

Nicolas Christou, MD, PhD, the director of bariatric surgery and a professor of surgery at McGill University, in Montreal, agrees. He says that gastric bypass is a more effective surgery and, as a result, may have greater effects on cancer risk in women—and men.

Dr. Christou conducted a study that showed men and women who had bariatric surgery were 78% less likely to develop any cancer, when compared with their equally overweight counterparts who did not undergo weight-loss surgery. He presented these findings at the 25th annual meeting of the American Society for Metabolic and Bariatric Surgery, in Washington, D.C.

However, any type of weight-loss surgery can have serious side effects or cause complications. In the study, 13% of people had complications of surgery, such as a bleeding, blood clots, infections, or other problems.