Treating Mild Pregnancy-Related Diabetes Is Good for Mom, Baby


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WEDNESDAY, Sept. 30, 2009 ( — Women who develop a mild case of gestational diabetes during pregnancy tend to have fewer complications and healthier babies if the diabetes is treated, according to the first large-scale randomized trial in the U.S. to address whether such treatment leads to health benefits for mother and child.

As many as 14% of pregnant women in the U.S., or about 200,000 women annually, develop gestational diabetes. This pregnancy-related diabetes can cause the fetus to grow too rapidly, and the excess weight can make delivery difficult and lead to complications. Whats more, gestational diabetes increases the risk of fetal death and preeclampsia, a potentially life-threatening rise in blood pressure in the mother.

However, the benefits of treating gestational diabetes are somewhat controversial; although most obstetricians screen and treat pregnant women for blood-sugar abnormalities, the 2008 guidelines of the U.S. Preventive Services Task Force has said there is not enough strong evidence for or against screening and treating gestational diabetes.

“Almost all obstetricians do screen for gestational diabetes, but some of them have not been particularly aggressive about treating milder cases, reserving aggressive treatment for people with higher blood-glucose results,” says lead study author Mark Landon, MD, of Ohio State University Medical Center, in Columbus. “For them, this study serves as notice that aggressive treatment with diet alone is useful for even mild gestational diabetes cases.”

Gestational diabetes can be treated with dietary restrictions, the oral drug metformin, or insulin injections. Dr. Landon says that, unfortunately, some women diagnosed with the condition are not even given a real meal plan to follow; instead they are simply advised to watch their sugar intake.

In the study, published in the New England Journal of Medicine, 958 women diagnosed with mild gestational diabetes between 24 and 31 weeks of pregnancy were divided into two groups; half were treated for diabetes, half were not. Women were considered to have mild gestational diabetes if they had an abnormal result after taking an oral glucose-tolerance test (a test in which women drink a sugary liquid and blood sugar is measured at regular intervals), but their fasting glucose level (a test in which blood sugar is measured after fasting) was below 95 milligrams per deciliter. Many doctors treat gestational diabetes only if it is more severe, generally considered to be 95 milligrams per deciliter or higher.

The new research, a partnership of 14 different institutions, showed that women were half as likely to have larger-than-normal babies if they were treated. For example, 14% of women who werent treated had a baby that weighed more than 8 pounds, 13 ounces, compared with only 6% who were treated.

The newborns also had fewer cases of shoulder dystocia (1.5% with treatment vs. 4% without treatment), a potential emergency in which the birthing process stalls due to entrapment of the infants shoulders—a problem thats more likely if a newborn is larger-than-normal. Women who were treated had fewer cases of high blood pressure or preeclampsia (8.6% vs. 13.6%) and were less likely to need a Caesarean section (about 27% vs. 33.8%) than women who were not.

David Sacks, MD, a maternal fetal medicine specialist at Kaiser Foundation Hospital, in Bellflower, Calif., says there is a disconnect between public health organizations and what doctors practice in terms of gestational diabetes. Most U.S. obstetricians have assumed that testing and treating the condition is beneficial, and the American Diabetes Association recommends screening for the condition.

“Gestational diabetes has been somewhat of an enigma for the last four decades because the benefits of treating it were not substantiated by strong evidence,” explains Dr. Sacks, who wrote an editorial that was published with the study. “Now we know that its a treatable disease and thats supported by solid science.”

Although treatment regimens are fairly well-established, Dr. Sacks says that exactly when women should be treated for gestational diabetes is still unclear. Whereas the current study used a fasting-glucose-test threshold of less than 95 milligrams per deciliter in women with an abnormal oral glucose tolerance test, another large-scale randomized trial published in 2005 by Australian researchers showed similar benefits using a much higher threshold of 140 milligrams per deciliter. “A uniform definition of gestational diabetes mellitus is necessary to make valid comparisons of the results of intervention trials,” writes Dr. Sacks.

According to Dr. Landon, new criteria for the testing and treatment of gestational diabetes are being considered and may eventually lead to more women being treated for the condition.

Most women in the U.S. are screened for gestational diabetes between 24 to 28 weeks of pregnancy but may be tested even earlier if they are very obese, have a strong family history of the condition, or if they had gestational diabetes or gave birth to a large baby during previous pregnancies. If a one-hour oral glucose test is positive for elevated blood sugar, then women generally undergo a similar three-hour test in order to be diagnosed.

Although gestational diabetes usually goes away after a woman gives birth, women who have the condition are 50% more likely to develop type 2 diabetes within the next 20 years. For that reason, the American Diabetes Association recommends occasional blood-sugar testing, a healthy diet, and regular exercise even after childbirth.